Technologies
The chemical proteomics technologies behind better drug discovery decisions
Every drug discovery program faces different challenges.
Understanding target engagement and selectivity within a specific enzyme class provides a more in-depth view than broad-spectrum proteomics, while avoiding the narrow focus of a single-target approach.
Omivera combines small-molecule probes with mass spectrometry to generate insights across an entire enzyme class, supporting better-informed drug discovery decisions. Our flagship product CellEKT allows researchers to see compound behaviour across the kinome.
CellEKT visualizes target engagement across multiple kinase families, helping reveal both intended activity and potential off-target interactions in biologically relevant systems.
Cellular target engagement profiling or Midostaurin
Midostaurin was profiled in a live acute myeloid leukemia cell line, MV4-11 cells, and target engagement was determined across 300+ kinases with each engaged kinase illustrated as a spike indicating the pEC50 value as determined across a full dose-response curve.
Understanding target engagement and selectivity within a specific enzyme class provides a more in-depth view than broad-spectrum proteomics, while avoiding the narrow focus of a single-target approach. Omivera combines small-molecule probes with mass spectrometry to generate insights across an entire enzyme class, supporting better-informed drug discovery decisions. Our flagship product CellEKT allows researchers to see compound behaviour across the kinome. It visualises target engagement across multiple kinase families, helping reveal both intended activity and potential off-target interactions in biologically relevant systems.
Which chemical proteomics technology is right for your programme?
Different drug discovery questions require different profiling strategies. Omivera helps you select the most appropriate technology based on your target class, compound modality, desired readout and biological model.
CellEKT
Quantify kinase target engagement and selectivity
Profile kinase inhibitors across biologically relevant systems to support compound selection and optimisation.
- Single-dose or dose-response profiling
- Cell and tissue lysates
- Living cells
- In vivo models
Activity-Based Protein Profiling
Measure functional enzymatic activity
Use ABPP to profile serine hydrolase inhibitors or investigate host-cell protein impurities.
- Proteomics-based readouts
- Gel-based assays
- Cell and tissue lysates
- Living cells
Tailored Chemical Proteomics
Build the right approach for your target
Develop a customised chemical proteomics strategy when established profiling methods do not fit your compound or target.
- Covalent inhibitor profiling
- Custom probe development
- Target engagement assay development
- Fit-for-purpose experimental design
Every Omivera technology is built on the same principles.
Endogenous proteins
Measure proteins in their native biological environment.
Biologically relevant systems
Generate data in living cells and complex biological models.
Mass spectrometry
Deep coverage across enzyme families with high sensitivity for quantitative analysis.
Cross-model profiling
Compare target engagement and activity across biological systems.
Actionable insights
Support confident compound prioritization
Our workflow
Every project starts with a scientific question. We work with you to define the objective, select the most appropriate chemical proteomics approach, and generate the data needed to support your next development decision.
Omivera is led by founders with expertise in chemical proteomics, medicinal chemistry and computational biology.
