{"id":203,"date":"2026-07-07T07:45:20","date_gmt":"2026-07-07T07:45:20","guid":{"rendered":"https:\/\/omivera.jppwebdesign.nl\/?page_id=203"},"modified":"2026-08-18T10:01:54","modified_gmt":"2026-08-18T10:01:54","slug":"capabilities","status":"publish","type":"page","link":"https:\/\/omivera.jppwebdesign.nl\/?page_id=203","title":{"rendered":"Capabilities"},"content":{"rendered":"

[et_pb_section fb_built=”1″ _builder_version=”4.27.6″ _module_preset=”default” use_background_color_gradient=”on” background_color_gradient_direction=”122deg” background_color_gradient_stops=”#001f52 0%|rgba(235,242,255,0.03) 99%” background_color_gradient_overlays_image=”on” background_image=”https:\/\/omivera.jppwebdesign.nl\/wp-content\/uploads\/2026\/06\/omi_Website-Omivera-9.png” background_enable_video_mp4=”off” global_colors_info=”{}”][et_pb_row column_structure=”1_2,1_2″ _builder_version=”4.27.6″ _module_preset=”default” min_height=”50vh” custom_css_main_element=”border-bottom: 5px solid;||border-image-slice: 1;||border-image-source: linear-gradient(|| 90deg,|| #ebf2ff 0%,|| #228cdb 50%,|| #001f52 100%||);||border-top: 0;||border-left: 0;||border-right: 0;” border_width_bottom=”5px” global_colors_info=”{}”][et_pb_column type=”1_2″ _builder_version=”4.27.6″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.27.6″ _module_preset=”default” header_font=”Hanken|300|||||||” header_text_color=”#FFFFFF” header_font_size=”40px” header_2_font=”–et_global_heading_font|100|||||||” header_2_text_color=”#B8DAF4″ header_2_font_size=”36px” header_2_line_height=”2em” global_colors_info=”{}”]<\/p>\n

CellEKT\u00a9<\/sup><\/h2>\n

Measure kinase target engagement and selectivity in native biological systems.<\/h1>\n

[\/et_pb_text][et_pb_button button_text=”Discuss your project” _builder_version=”4.27.6″ _module_preset=”default” custom_button=”on” button_text_size=”18px” button_text_color=”#FFFFFF” button_bg_color=”#228CDB” button_border_width=”0px” button_border_radius=”5px” button_font=”Hanken||||||||” global_colors_info=”{}”][\/et_pb_button][et_pb_image src=”https:\/\/omivera.jppwebdesign.nl\/wp-content\/uploads\/2026\/06\/omi_Website-Omivera-26.png” title_text=”omi_Website Omivera (26)” _builder_version=”4.27.6″ _module_preset=”default” max_width=”3vw” global_colors_info=”{}”][\/et_pb_image][\/et_pb_column][et_pb_column type=”1_2″ _builder_version=”4.27.6″ _module_preset=”default” global_colors_info=”{}”][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”4.27.6″ _module_preset=”default” custom_padding=”10vh||||false|false” global_colors_info=”{}”][et_pb_row _builder_version=”4.27.6″ _module_preset=”default” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.27.6″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.27.6″ _module_preset=”default” text_font=”Hanken||||||||” text_text_color=”#000000″ header_2_font=”Hanken|200|||||||” header_2_text_color=”#000000″ header_2_font_size=”32px” header_2_line_height=”1.2em” global_colors_info=”{}”]<\/p>\n

CellEKT is Omivera’s chemical proteomics platform for measuring kinase target engagement and selectivity directly in endogenous biological systems. Generate quantitative data across cell lines, primary cells, patient-derived models, and tissues to support confident drug discovery decisions.<\/h2>\n

 <\/p>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”1_4,3_4″ use_custom_gutter=”on” gutter_width=”1″ disabled_on=”on|on|on” _builder_version=”4.27.6″ _module_preset=”default” custom_padding=”0px||0px||true|false” disabled=”on” global_colors_info=”{}”][et_pb_column type=”1_4″ _builder_version=”4.27.6″ _module_preset=”default” custom_padding=”2vh||2vh||true|false” global_colors_info=”{}”][et_pb_text _builder_version=”4.27.6″ _module_preset=”default” text_font=”Hanken|200|||||||” text_text_color=”#000000″ text_font_size=”28px” text_orientation=”center” global_colors_info=”{}”]<\/p>\n

Applications<\/p>\n

[\/et_pb_text][\/et_pb_column][et_pb_column type=”3_4″ _builder_version=”4.27.6″ _module_preset=”default” background_color=”#228CDB” custom_padding=”2vh|2vw|2vh|2vw|true|true” border_radii=”on|1vh|1vh|1vh|1vh” global_colors_info=”{}”][et_pb_text _builder_version=”4.27.6″ _module_preset=”default” text_font_size=”12px” text_letter_spacing=”-0.2px” background_layout=”dark” global_colors_info=”{}”]\u2713 Lead optimization \u2713 Candidate selection \u2713 Selectivity assessment \u2713 Mechanism-of-action studies \u2713 Translational research[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”1_4,3_4″ use_custom_gutter=”on” gutter_width=”1″ disabled_on=”on|on|on” _builder_version=”4.27.6″ _module_preset=”default” custom_padding=”||||true|false” disabled=”on” global_colors_info=”{}”][et_pb_column type=”1_4″ _builder_version=”4.27.6″ _module_preset=”default” custom_padding=”2vh||2vh||true|false” global_colors_info=”{}”][et_pb_text _builder_version=”4.27.6″ _module_preset=”default” text_font=”Hanken|200|||||||” text_text_color=”#000000″ text_font_size=”28px” text_orientation=”center” global_colors_info=”{}”]<\/p>\n

Key outputs<\/p>\n

[\/et_pb_text][\/et_pb_column][et_pb_column type=”3_4″ _builder_version=”4.27.6″ _module_preset=”default” background_enable_color=”off” use_background_color_gradient=”on” background_color_gradient_type=”circular” background_color_gradient_direction_radial=”top left” background_color_gradient_stops=”#001f52 41%|#228cdb 100%” custom_padding=”2vh|2vw|2vh|2vw|true|true” border_radii=”on|1vh|1vh|1vh|1vh” global_colors_info=”{}”][et_pb_text _builder_version=”4.27.6″ _module_preset=”default” text_font_size=”12px” text_letter_spacing=”-0.2px” background_layout=”dark” global_colors_info=”{}”]\u2713 Kinome-wide target engagement profiles \u2713 Dose-response analysis \u2713 Off-target identification \u2713 Candidate prioritization support[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”2_3,1_3″ use_custom_gutter=”on” gutter_width=”2″ make_equal=”on” _builder_version=”4.27.6″ _module_preset=”default” global_colors_info=”{}”][et_pb_column type=”2_3″ _builder_version=”4.27.6″ _module_preset=”default” background_color=”#001F52″ custom_padding=”5vh|3vw|5vh|3vw|true|true” border_radii=”on|1vh|1vh|1vh|1vh” global_colors_info=”{}”][et_pb_text _builder_version=”4.27.6″ _module_preset=”default” text_text_color=”#FFFFFF” header_2_text_color=”#FFFFFF” header_2_line_height=”1.6em” global_colors_info=”{}”]<\/p>\n

What questions can CellEKT answer?<\/h2>\n

\u2713 Does my compound engage its intended kinase in a native biological system?<\/p>\n

\u2713 How selective is my compound across the kinome?<\/p>\n

\u2713 How much target engagement is achieved at a given concentration or dose?<\/p>\n

\u2713 Does target engagement translate across biologically relevant models?<\/p>\n

[\/et_pb_text][\/et_pb_column][et_pb_column type=”1_3″ _builder_version=”4.27.6″ _module_preset=”default” background_image=”https:\/\/omivera.jppwebdesign.nl\/wp-content\/uploads\/2026\/06\/omi_Website-Omivera-11.png” border_radii=”on|1vh|1vh|1vh|1vh” global_colors_info=”{}”][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”1_3,1_3,1_3″ _builder_version=”4.27.6″ _module_preset=”default” background_color=”#EBF2FF” custom_padding=”3vh|2vw|3vh|2vw|true|true” border_radii=”on|2vh|2vh|2vh|2vh” global_colors_info=”{}”][et_pb_column type=”1_3″ _builder_version=”4.27.6″ _module_preset=”default” custom_padding=”|1vw||0vw|false|false” border_color_all=”#FFFFFF” border_width_right=”2px” global_colors_info=”{}”][et_pb_text _builder_version=”4.27.6″ _module_preset=”default” global_colors_info=”{}”]<\/p>\n\n\n\n\n\n\n\n\n\n
\n

Model<\/strong><\/span><\/h3>\n<\/td>\n<\/tr>\n<\/thead>\n

Cell lines<\/span><\/td>\n<\/tr>\n
Organoids<\/span><\/td>\n<\/tr>\n
PBMCs<\/span><\/td>\n<\/tr>\n
In vivo tissues<\/span><\/td>\n<\/tr>\n
Clinical samples<\/em><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

[\/et_pb_text][\/et_pb_column][et_pb_column type=”1_3″ _builder_version=”4.27.6″ _module_preset=”default” custom_padding=”|1vw|||false|false” border_width_right=”2px” border_color_right=”#FFFFFF” global_colors_info=”{}”][et_pb_text _builder_version=”4.27.6″ _module_preset=”default” global_colors_info=”{}”]<\/p>\n\n\n\n\n\n\n\n\n\n
\n

Coverage<\/strong><\/span><\/h3>\n<\/td>\n<\/tr>\n<\/thead>\n

300\u2013400 kinases<\/td>\n<\/tr>\n
300\u2013400 kinases<\/td>\n<\/tr>\n
Up to 350 kinases<\/td>\n<\/tr>\n
200+ kinases\/tissue<\/td>\n<\/tr>\n
Open for collaboration<\/em><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

[\/et_pb_text][\/et_pb_column][et_pb_column type=”1_3″ _builder_version=”4.27.6″ _module_preset=”default” custom_padding=”||||false|false” global_colors_info=”{}”][et_pb_text _builder_version=”4.27.6″ _module_preset=”default” global_colors_info=”{}”]<\/p>\n\n\n\n\n\n\n\n\n
\n

Best suited for<\/strong><\/span><\/h3>\n<\/td>\n<\/tr>\n<\/thead>\n

\n

Hit validation & lead optimization<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

Disease-relevant biology<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

Translational research<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

Physiological target engagement<\/span><\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”1_2,1_2″ make_equal=”on” _builder_version=”4.27.6″ _module_preset=”default” global_colors_info=”{}”][et_pb_column type=”1_2″ _builder_version=”4.27.6″ _module_preset=”default” background_color=”#EBF2FF” background_enable_image=”off” background_blend=”multiply” custom_padding=”6vh|2vw|6vh|2vw|true|true” border_radii=”on|1vh|1vh|1vh|1vh” global_colors_info=”{}” background__hover_enabled=”off|desktop” background_color_gradient_stops__hover=”#001f52 55%|#228cdb 100%” use_background_color_gradient__hover=”on”][dmpro_carousel columns=”1″ pagination=”on” pagination_color=”#228CDB” pagination_active_color=”#CE4257″ _builder_version=”4.27.6″ _module_preset=”default” global_colors_info=”{}”][dmpro_carousel_child title=”1″ img_src=”https:\/\/omivera.jppwebdesign.nl\/wp-content\/uploads\/2026\/07\/omi_Website-Omivera-51.png” text_title=”1. The drug is added to disease-relevant living cells or organoids.” img_width=”35%” _builder_version=”4.27.6″ _module_preset=”default” custom_padding=”||||false|false” border_radii_img=”on|1vh|1vh|1vh|1vh” border_width_all_img=”2px” border_color_all_img=”#228CDB” global_colors_info=”{}”][\/dmpro_carousel_child][dmpro_carousel_child title=”2″ img_src=”https:\/\/omivera.jppwebdesign.nl\/wp-content\/uploads\/2026\/07\/omi_Website-Omivera-52.png” text_title=”2. Patented kinase probes are added to the cells or organoids.” img_width=”35%” _builder_version=”4.27.6″ _module_preset=”default” custom_padding=”||||false|false” border_radii_img=”on|1vh|1vh|1vh|1vh” border_width_all_img=”2px” border_color_all_img=”#228CDB” global_colors_info=”{}”][\/dmpro_carousel_child][dmpro_carousel_child title=”3″ img_src=”https:\/\/omivera.jppwebdesign.nl\/wp-content\/uploads\/2026\/07\/omi_Website-Omivera-54.png” text_title=”3. Mass spectrometry identifies and quantifies all labelled kinases.” img_width=”35%” _builder_version=”4.27.6″ _module_preset=”default” custom_padding=”||||false|false” border_radii_img=”on|1vh|1vh|1vh|1vh” border_width_all_img=”2px” border_color_all_img=”#228CDB” global_colors_info=”{}”][\/dmpro_carousel_child][dmpro_carousel_child title=”4″ img_src=”https:\/\/omivera.jppwebdesign.nl\/wp-content\/uploads\/2026\/07\/omi_Website-Omivera-53.png” text_title=”4. Compare treated vs untreated cells to reveal drug-target engagement.” img_width=”35%” _builder_version=”4.27.6″ _module_preset=”default” custom_padding=”||||false|false” border_radii_img=”on|1vh|1vh|1vh|1vh” border_width_all_img=”2px” border_color_all_img=”#228CDB” global_colors_info=”{}”][\/dmpro_carousel_child][\/dmpro_carousel][\/et_pb_column][et_pb_column type=”1_2″ _builder_version=”4.27.6″ _module_preset=”default” background_video_mp4=”https:\/\/omivera.jppwebdesign.nl\/wp-content\/uploads\/2026\/07\/omi_clips_website-3.mp4″ border_radii=”on|2vh|2vh|2vh|2vh” global_colors_info=”{}”][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”2_3,1_3″ use_custom_gutter=”on” gutter_width=”2″ make_equal=”on” _builder_version=”4.27.6″ _module_preset=”default” hover_enabled=”0″ global_colors_info=”{}” sticky_enabled=”0″][et_pb_column type=”2_3″ _builder_version=”4.27.6″ _module_preset=”default” background_color=”#001F52″ custom_padding=”5vh|3vw|5vh|3vw|true|true” border_radii=”on|1vh|1vh|1vh|1vh” global_colors_info=”{}”][et_pb_text _builder_version=”4.27.6″ _module_preset=”default” text_text_color=”#FFFFFF” header_2_text_color=”#FFFFFF” header_2_line_height=”1.6em” global_colors_info=”{}”]<\/p>\n

Flexible study designs<\/h2>\n

[\/et_pb_text][et_pb_text _builder_version=”4.27.6″ _module_preset=”default” text_text_color=”#FFFFFF” header_2_text_color=”#FFFFFF” header_2_line_height=”1.6em” global_colors_info=”{}”]<\/p>\n\n\n\n\n\n\n
\n

High-throughput profiling<\/span><\/strong><\/p>\n<\/td>\n

\n

Quantitative dose-response<\/span><\/strong><\/p>\n<\/td>\n<\/tr>\n<\/thead>\n

\n

Screen many compounds at a single concentration<\/p>\n<\/td>\n

\n

Profile selected compounds in a full dose response curve<\/p>\n<\/td>\n<\/tr>\n

\n

Rapid prioritization<\/span><\/p>\n<\/td>\n

\n

Lead optimization & candidate selection<\/span><\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

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CellEKT helps you generate biologically relevant profiling data for lead optimization and preclinical planning.<\/span><\/p>\n

It is built on proprietary kinase probe technology developed through years of chemical proteomics research.<\/span><\/p>\n

[\/et_pb_text][\/et_pb_column][et_pb_column type=”1_2″ _builder_version=”4.27.6″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.27.6″ _module_preset=”default” text_font=”Hanken|800|||||||” text_text_color=”#FFFFFF” text_font_size=”28px” global_colors_info=”{}”]\u2192 Supporting Evidence<\/p>\n

\u2192 Patented kinase probes<\/p>\n

\u2192 Broad kinome coverage<\/p>\n

\u2192 Peer-reviewed scientific validation<\/p>\n

\u2192 Ongoing platform development[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”4.27.6″ _module_preset=”default” global_colors_info=”{}”][et_pb_row _builder_version=”4.27.6″ _module_preset=”default” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.27.6″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.27.6″ _module_preset=”default” text_font=”Hanken||||||||” text_text_color=”#000000″ header_2_font=”Hanken|200|||||||” header_2_text_color=”#000000″ header_2_font_size=”32px” global_colors_info=”{}”]<\/p>\n

Built on validated chemical proteomics expertise.<\/h2>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”1_2,1_2″ make_equal=”on” _builder_version=”4.27.6″ _module_preset=”default” global_colors_info=”{}”][et_pb_column type=”1_2″ _builder_version=”4.27.6″ _module_preset=”default” background_enable_color=”off” custom_padding=”||||true|true” global_colors_info=”{}”][et_pb_text _builder_version=”4.27.6″ _module_preset=”default” text_font=”Hanken||||||||” text_text_color=”#FFFFFF” header_2_font=”Hanken||||||||” header_2_font_size=”32px” header_3_font=”Hanken|200|||||||” background_color=”#001F52″ background_layout=”dark” custom_margin=”||||false|false” custom_padding=”3vh|2vw|3vh|2vw|true|true” border_radii=”on|2vh|2vh|2vh|2vh” global_colors_info=”{}”]<\/p>\n

Big pharma collaboration<\/span><\/h2>\n

Omivera\u2019s technology is being applied in collaboration with a large pharmaceutical company, supporting the translation of CellEKT from academic research into real drug discovery settings.<\/span><\/p>\n

[\/et_pb_text][et_pb_text _builder_version=”4.27.6″ _module_preset=”default” text_font=”Hanken||||||||” text_text_color=”#FFFFFF” header_2_font=”Hanken||||||||” header_2_font_size=”32px” header_3_font=”Hanken|200|||||||” background_color=”#228CDB” background_layout=”dark” custom_padding=”3vh|2vw|3vh|2vw|true|true” border_radii=”on|2vh|2vh|2vh|2vh” global_colors_info=”{}”]<\/p>\n

Cover > 90% of the kinome<\/span><\/h2>\n

CellEKT has been used to build a strong reference base of profiled kinases.<\/span><\/p>\n

[\/et_pb_text][et_pb_text _builder_version=”4.27.6″ _module_preset=”default” text_font=”Hanken||||||||” text_text_color=”#FFFFFF” header_2_font=”Hanken||||||||” header_2_font_size=”32px” header_3_font=”Hanken|200|||||||” background_color=”#6facdb” background_layout=”dark” custom_padding=”3vh|2vw|3vh|2vw|true|true” border_radii=”on|2vh|2vh|2vh|2vh” global_colors_info=”{}”]<\/p>\n

Published Validation Study<\/h2>\n

The CellEKT platform is supported by peer-reviewed research, giving teams a scientific basis for using the technology in kinase inhibitor profiling.<\/p>\n

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CellEKT\u00a9 Measure kinase target engagement and selectivity in native biological systems.CellEKT is Omivera’s chemical proteomics platform for measuring kinase target engagement and selectivity directly in endogenous biological systems. Generate quantitative data across cell lines, primary cells, patient-derived models, and tissues to support confident drug discovery decisions.  Applications\u2713 Lead optimization \u2713 Candidate selection \u2713 Selectivity assessment […]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"class_list":["post-203","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/omivera.jppwebdesign.nl\/index.php?rest_route=\/wp\/v2\/pages\/203","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/omivera.jppwebdesign.nl\/index.php?rest_route=\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/omivera.jppwebdesign.nl\/index.php?rest_route=\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/omivera.jppwebdesign.nl\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/omivera.jppwebdesign.nl\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=203"}],"version-history":[{"count":19,"href":"https:\/\/omivera.jppwebdesign.nl\/index.php?rest_route=\/wp\/v2\/pages\/203\/revisions"}],"predecessor-version":[{"id":392,"href":"https:\/\/omivera.jppwebdesign.nl\/index.php?rest_route=\/wp\/v2\/pages\/203\/revisions\/392"}],"wp:attachment":[{"href":"https:\/\/omivera.jppwebdesign.nl\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=203"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}